Anvar Mirzaei

Associate professor, Azad University, Sanandaj, Iran. mirzaei.anvar@gmail.com                


In recent times, diversity-oriented synthesis (DOS) from small chemical entities has emerged out as a possible approach to explore intersections between different research fields, such as the biological activities of new synthesized organic molecules are studied. These molecules can not only be used as probes for biological targets, but also as modulators for disease states. On the other hand, multicomponent reactions (MCRs) can be defined as convergent chemical processes where three or more reagents are combined in such a way that the final product retains significant portions of all starting materials.

Developing structurally complex and diverse bioactive molecules, synthetic chemists always pay attention to the efficient complexity for generating reactions by using small and simple building blocks in a single operation. It may result in a multifunctional product that becomes a substrate for another moiety that generates significant reactions. Examples of such reactions include Passerini reaction, Ugi reaction, Diels-Alder reaction, Biginelli reaction, Morita-Baylis-Hillman reaction, Groebke-Blackburn-Bienaymé (GBB) reaction, and so on.

In addition to the development of new reactions or improved conditions for classical ones, future progresses in this field are likely to involve the implementation of multicomponent based strategies for target-oriented synthesis (TOS).


References

1. N. Devi, R. K. Rawal and V. Singh, Tetrahedron, 2015, 71, 183–232.

2. C. De Graaff, E. Ruijter and R. V. A. Orru, Chem. Soc. Rev, 2012, 41, 3969–4009.

3. A. Dömling and I. Ugi, Angew. Chemie Int. Ed. English, 1993, 32, 563–564.


About the Author

Dr Anvar Mirzaei was graduated from Tarbiat Modares Univesity, Iran. He has worked in Uppsala University, Sweeden during his PhD. He finished his Postdoc in the Chinese University of Hong Kong and has also worked in Hungarian Academy of sciences for a short time.